KTM2A trimethylates nucleosomes at the Spi1 gene locus producing H3K4Me3 mark

authored
catalystActivity
catalystActivityReference [CatalystActivityReference:9643793] histone methyltransferase activity (H3-K4 specific) of RUNX1:Cbfb:KMT2A:Spi1 gene:Nucleosome [nucleoplasm] The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
category transition
compartment
created [InstanceEdit:8865524] Orlic-Milacic, Marija, 2016-03-22
dbId 8865525
displayName KTM2A trimethylates nucleosomes at the Spi1 gene locus producing H3K4Me3 mark
edited
input
isChimeric true
isInDisease false
isInferred false
literatureReference
maxDepth 1
modified [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
  • KTM2A trimethylates nucleosomes at the Spi1 gene locus producing H3K4Me3 mark
orthologousEvent
output
releaseDate 2017-06-12
reviewStatus [ReviewStatus:9821382] five stars
reviewed
schemaClass Reaction
species
stId R-NUL-8865525
summation
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