Reactome | E-cadherin strand dimer degradation by MMP3, MMP7 and Plasmin

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E-cadherin strand dimer degradation by MMP3, MMP7 and Plasmin Show undefined attributes

authored	[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity	[CatalystActivity:2534249] serine-type endopeptidase activity of MMP3, MMP7, Plasmin [extracellular region]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2534268] Jupe, S, 2012-10-24
dbId	2534162
displayName	E-cadherin strand dimer degradation by MMP3, MMP7 and Plasmin
edited	[InstanceEdit:4090280] Jupe, S, 2013-08-13
input	[GenomeEncodedEntity:R-CFA-2534284] Cadherin-1 [plasma membrane]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1454764] Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1 [LiteratureReference:2534223] Plasmin produces an E-cadherin fragment that stimulates cancer cell invasion
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E-cadherin strand dimer degradation by MMP3, MMP7 and Plasmin
orthologousEvent	[Reaction:R-HSA-1454843] E-cadherin degradation by MMP3, MMP7 and plasmin - Homo sapiens
output	[GenomeEncodedEntity:R-CFA-2534168] Cadherin-1 C-term fragment [plasma membrane] [GenomeEncodedEntity:R-CFA-2534172] Cadherin-1 N-term fragment [plasma membrane]
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens [Species:49646] Canis familiaris
stId	R-NUL-2534162
summation	[Summation:3827983] Full-length 120-kDa CDH1 protein is cleaved in the ectodomai...

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