Reactome | SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST)

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SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10102015
displayName	SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST)
eventOf	[Pathway:R-MMU-9958825] Activation of STAT3 by cadherin engagement - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-MMU-9958892] SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs - Mus musculus [BlackBoxEvent:R-MMU-9970163] SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42) - Mus musculus [Reaction:R-MMU-9958889] SRC phosphorylates CDH1 - Mus musculus [Reaction:R-MMU-9934755] CBLL1 binds p-Y-CDH1 - Mus musculus [Reaction:R-MMU-9934753] CBLL1 ubiquitinates CDH1 - Mus musculus [BlackBoxEvent:R-MMU-9934752] Ubiquitinated CDH1 is endocytosed - Mus musculus [BlackBoxEvent:R-MMU-9935552] Ubiquitinated CDH1 translocates to lysosomes for degradation - Mus musculus [BlackBoxEvent:R-MMU-9935547] Lysosomal degradation of ubiquitinated CDH1 - Mus musculus
inferredFrom	[Pathway:R-HSA-9958810] SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-9958810
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9958825] Activation of STAT3 by cadherin engagement
(inferredTo)	[Pathway:R-HSA-9958810] SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST)

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