Reactome | MBD2, MBD3 and GATAD2A, GATAD2B bind core NuRD complex

Schema > Reaction > Entries

MBD2, MBD3 and GATAD2A, GATAD2B bind core NuRD complex Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10097473
displayName	MBD2, MBD3 and GATAD2A, GATAD2B bind core NuRD complex
eventOf	[Pathway:R-MMU-9937850] NuRD complex assembly - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9940474] MBD3L2 binds MBD3 NuRD core complex - Mus musculus [Reaction:R-MMU-9941683] MBD3L1 binds MBD2 NuRD core complex - Mus musculus [Reaction:R-MMU-9940468] CHD and CDK2AP subunits are recruited to NuRD - Mus musculus
inferredFrom	[Reaction:R-HSA-9940462] MBD2, MBD3 and GATAD2A, GATAD2B bind core NuRD complex - Homo sapiens
input	[Complex:R-MMU-9938417] HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] [DefinedSet:R-MMU-9940422] MBD2,MBD3 [nucleoplasm] [DefinedSet:R-MMU-9940428] SUMO1-GATAD2A, SUMO1-GATAD2B [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MBD2, MBD3 and GATAD2A, GATAD2B bind core NuRD complex
output	[Complex:R-MMU-9940439] HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm]
precedingEvent	[Reaction:R-MMU-9938418] HDAC1, 2 bind MTA1, 2, 3 and RBBP4,7 - Mus musculus [Reaction:R-MMU-9940470] GATAD2A is SUMOylated - Mus musculus [Reaction:R-MMU-9940458] GATAD2B is SUMOylated - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9940462
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9937850] NuRD complex assembly
(precedingEvent)	[Reaction:R-MMU-9940474] MBD3L2 binds MBD3 NuRD core complex [Reaction:R-MMU-9941683] MBD3L1 binds MBD2 NuRD core complex [Reaction:R-MMU-9940468] CHD and CDK2AP subunits are recruited to NuRD
(inferredTo)	[Reaction:R-HSA-9940462] MBD2, MBD3 and GATAD2A, GATAD2B bind core NuRD complex