Reactome | Proteolysis of K48polyUb-K107,p-S-Cry1,K48polyUb-K125,p-S-Cry2

Schema > BlackBoxEvent > Entries

Proteolysis of K48polyUb-K107,p-S-Cry1,K48polyUb-K125,p-S-Cry2 Show undefined attributes

authored	[InstanceEdit:9934882] May, Bruce, 2025-01-11
catalystActivity	[CatalystActivity:1236950] endopeptidase activity of m26S Proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9934885] May, Bruce, 2025-01-12
dbId	9934888
displayName	Proteolysis of K48polyUb-K107,p-S-Cry1,K48polyUb-K125,p-S-Cry2
edited	[InstanceEdit:9934882] May, Bruce, 2025-01-11
input	[DefinedSet:R-MMU-9933311] K48polyUb-K107,p-S-Cry1,K48polyUb-K125,p-S-Cry2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9932516] Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm [LiteratureReference:9932876] FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Proteolysis of K48polyUb-K107,p-S-Cry1,K48polyUb-K125,p-S-Cry2
orthologousEvent	[BlackBoxEvent:R-HSA-9934887] Proteolysis of K48polyUb-K107,p-S-CRY1,K48polyUb-K126,p-S-CRY2 - Homo sapiens
output	3 × [CandidateSet:R-MMU-517946] Ubiquitin [cytosol]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9934888
summation	[Summation:9934886] The proteasome degrades K48-polyubiquitinylated Cry1 and Cry...

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