Reactome | p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Kmt2a:Cry1 gene [nucleoplasm]

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p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Kmt2a:Cry1 gene [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9933419] May, Bruce, 2024-12-30
dbId	9933424
displayName	p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Kmt2a:Cry1 gene [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-MMU-5663188] Cry1 gene [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5624510] Kmt2a [nucleoplasm] 2 × [Complex:R-MMU-9933414] p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-HSA-9933413] p-S90-BMAL1:p-T451,T461-CLOCK,p-S-NPAS2:KMT2A:CRY1 gene [nucleoplasm] - Homo sapiens
isChimeric	false
literatureReference	[LiteratureReference:549497] Rhythmic histone acetylation underlies transcription in the mammalian circadian clock [LiteratureReference:9926624] Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex [LiteratureReference:9926607] Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates [LiteratureReference:9036813] Mammalian Period represses and de-represses transcription by displacing CLOCK-BMAL1 from promoters in a Cryptochrome-dependent manner [LiteratureReference:5669331] Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver [LiteratureReference:9929333] Transcriptional architecture and chromatin landscape of the core circadian clock in mammals [LiteratureReference:9929279] The histone methyltransferase MLL1 permits the oscillation of circadian gene expression
maxDepth	4
name	p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Kmt2a:Cry1 gene
positivelyRegulates	[PositiveGeneExpressionRegulation:9926591] Positive gene expression regulation by 'p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Kmt2a:Cry1 gene [nucleoplasm]'
producedByEvent	[Reaction:R-MMU-9926600] p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 and coactivators bind the Cry1 gene - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-9933424

Referrals

(regulator)	[PositiveGeneExpressionRegulation:9926591] Positive gene expression regulation by 'p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Kmt2a:Cry1 gene [nucleoplasm]'
(output)	[Reaction:R-MMU-9926600] p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 and coactivators bind the Cry1 gene

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