Reactome | p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Crebbp:Kmt2a:Per2 gene [nucleoplasm]

Schema > Complex > Entries

p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Crebbp:Kmt2a:Per2 gene [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9933419] May, Bruce, 2024-12-30
dbId	9933416
displayName	p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Crebbp:Kmt2a:Per2 gene [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-MMU-556795] Crebbp [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5624510] Kmt2a [nucleoplasm] 2 × [Complex:R-MMU-9933414] p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5663150] Per2 gene [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-HSA-9933423] p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2:CREBBP:KMT2A:PER2 gene [nucleoplasm] - Homo sapiens
isChimeric	false
literatureReference	[LiteratureReference:9926624] Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex [LiteratureReference:5669331] Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver [LiteratureReference:9929279] The histone methyltransferase MLL1 permits the oscillation of circadian gene expression [LiteratureReference:9929333] Transcriptional architecture and chromatin landscape of the core circadian clock in mammals [LiteratureReference:400229] A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes [LiteratureReference:9933420] Changes in pH and NADPH regulate the DNA binding activity of neuronal PAS domain protein 2, a mammalian circadian transcription factor [LiteratureReference:879766] NPAS2: an analog of clock operative in the mammalian forebrain
maxDepth	4
name	p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Crebbp:Kmt2a:Per2 gene
positivelyRegulates	[PositiveGeneExpressionRegulation:9926588] Positive gene expression regulation by 'p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Crebbp:Kmt2a:Per2 gene [nucleoplasm]'
producedByEvent	[Reaction:R-MMU-9926612] p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 and coactivators bind the Per2 gene - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-9933416

Referrals

(regulator)	[PositiveGeneExpressionRegulation:9926588] Positive gene expression regulation by 'p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Crebbp:Kmt2a:Per2 gene [nucleoplasm]'
(output)	[Reaction:R-MMU-9926612] p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 and coactivators bind the Per2 gene

© 2026 Reactome

Cite Us!