Reactome | Proteasomal degradation of polyUb-p-S195-CD274

Schema > Reaction > Entries

Proteasomal degradation of polyUb-p-S195-CD274 Show undefined attributes

catalystActivity	[CatalystActivity:9985423] endopeptidase activity of 26S proteasome [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10096845
displayName	Proteasomal degradation of polyUb-p-S195-CD274
eventOf	[Pathway:R-MMU-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9931314] Proteasomal degradation of polyUb-p-S195-CD274 - Homo sapiens
input	[Complex:R-MMU-9931275] polyUb-p-S195-CD274 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Proteasomal degradation of polyUb-p-S195-CD274
output	[DefinedSet:R-MMU-113595] Ub [cytosol]
precedingEvent	[Reaction:R-MMU-9931264] Active transport of ubiquitinated CD274 from ER to cytosol - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9931314
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
(inferredTo)	[Reaction:R-HSA-9931314] Proteasomal degradation of polyUb-p-S195-CD274

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