Reactome | Phosphorylated Bmal1:Clock positively regulates expression of Dbp

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Phosphorylated Bmal1:Clock positively regulates expression of Dbp Show undefined attributes

authored	[InstanceEdit:9929284] May, Bruce, 2024-11-23
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9929329] May, Bruce, 2024-11-24
dbId	9929327
deleted	[Deleted:9938400] Deletion of instance: 879748 [Deleted:9032447] Deletion of instance: 1368110 [Deleted:9032440] Deletion of instance: 5334727
displayName	Phosphorylated Bmal1:Clock positively regulates expression of Dbp
edited	[InstanceEdit:9929284] May, Bruce, 2024-11-23
input	[EntityWithAccessionedSequence:R-MMU-5663192] Dbp gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9929958] Role of DBP in the circadian oscillatory mechanism [LiteratureReference:9929971] The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior [LiteratureReference:9929948] Distribution and circadian expression of dbp in SCN and extra-SCN areas in the mouse brain [LiteratureReference:9929956] Flexible phase adjustment of circadian albumin D site-binding protein (DBP) gene expression by CRYPTOCHROME1 [LiteratureReference:879735] CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP [LiteratureReference:879774] Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Phosphorylated Bmal1:Clock positively regulates expression of Dbp
orthologousEvent	[BlackBoxEvent:R-HSA-9929321] Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of DBP - Homo sapiens
output	[EntityWithAccessionedSequence:R-MMU-879758] Dbp [nucleoplasm]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9929252] Positive gene expression regulation by 'p-S97-Bmal1:p-T451,T461-Clock:Crebbp:Kmt2a:Dbp gene [nucleoplasm]'
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9929327
summation	[Summation:9930003] Phosphorylated Bmal1:Clock binds E-boxes in the promoter of ...

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