Reactome | 2Fe-2S is inserted in UQCRFS1

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2Fe-2S is inserted in UQCRFS1 Show undefined attributes

catalystActivity	[CatalystActivity:10095949] iron chaperone activity of FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10095951
displayName	2Fe-2S is inserted in UQCRFS1
eventOf	[Pathway:R-MMU-9865881] Complex III assembly - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9866253] apo-UQCRFS1 binds LYRM7 - Mus musculus
inferredFrom	[Reaction:R-HSA-9866272] 2Fe-2S is inserted in UQCRFS1 - Homo sapiens
input	[Complex:R-MMU-1362398] FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] [Complex:R-MMU-9866263] UQCRFS1(1-274):LYRM7 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	2Fe-2S is inserted in UQCRFS1
output	[Complex:R-MMU-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] [Complex:R-MMU-164304] holo-UQCRFS1(1-274) [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-MMU-9866252] Lyrm7 [mitochondrial matrix]
precedingEvent	[Reaction:R-MMU-9866253] apo-UQCRFS1 binds LYRM7 - Mus musculus
regulatedBy	[Requirement:10066080] Requirement by 'HSPA9:HSCB [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9866272
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9865881] Complex III assembly
(precedingEvent)	[Reaction:R-MMU-9866253] apo-UQCRFS1 binds LYRM7
(inferredTo)	[Reaction:R-HSA-9866272] 2Fe-2S is inserted in UQCRFS1