Reactome | Pecam1:Cdh5:Pik3ca,b,d:p-Y458-Pik3r2:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1 [plasma membrane]

Schema > Complex > Entries

Pecam1:Cdh5:Pik3ca,b,d:p-Y458-Pik3r2:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1 [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:9863597] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Pecam1:Cdh5:Pik3ca,b,d:p-Y458-Pik3r2:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9860568] May, Bruce, 2024-02-07
dbId	9860575
displayName	Pecam1:Cdh5:Pik3ca,b,d:p-Y458-Pik3r2:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-MMU-9860478] Cdh5 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-9761458] Ctnnb1 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-9860573] p-Y1063,Y1230-Flt4 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-9860466] Pecam1 [plasma membrane] [Complex:R-MMU-9860565] Pik3ca,b,d:p-Y458-Pik3r2:p-Y799,Y1052,Y1172-Kdr [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-HSA-9860549] p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] - Homo sapiens
isChimeric	false
literatureReference	[LiteratureReference:9860495] A mechanosensory complex that mediates the endothelial cell response to fluid shear stress [LiteratureReference:9860463] Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex
maxDepth	5
name	Pecam1:Cdh5:Pik3ca,b,d:p-Y458-Pik3r2:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1
producedByEvent	[BlackBoxEvent:R-MMU-9860560] Phosphorylation of Pi3k in Pecam1:Cdh5:PiK3ca,b,d:Pik3r2:p-799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1 - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-9860575

Referrals

(physicalEntity)	[CatalystActivity:9863597] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Pecam1:Cdh5:Pik3ca,b,d:p-Y458-Pik3r2:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1 [plasma membrane]
(output)	[BlackBoxEvent:R-MMU-9860560] Phosphorylation of Pi3k in Pecam1:Cdh5:PiK3ca,b,d:Pik3r2:p-799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1

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