Reactome | prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface)

Schema > Reaction > Entries

prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) Show undefined attributes

catalystActivity	[CatalystActivity:10089290] serine-type endopeptidase activity of KLKB1:KNG1:(C1QBP,C1QBP:KRT1, PLAUR:KRT1):FXII [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10095404
displayName	prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface)
eventOf	[Pathway:R-MMU-9970672] FXIIa activates plasma kallikrein-kinin system - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst) - Mus musculus [Reaction:R-MMU-9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) - Mus musculus [Reaction:R-MMU-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - Mus musculus
inferredFrom	[Reaction:R-HSA-9857814] prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) - Homo sapiens
input	[Complex:R-MMU-9857822] KLKB1:KNG1:(C1QBP,C1QBP:KRT1, PLAUR:KRT1):FXII [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) KLKB1:KNG1:(C1QBP,C1QBP:KRT1, PLAUR:KRT1):FXII -> FXIIa + KLKB1:KNG1:(C1QBP, C1QBP:KRT1, PLAUR:KRT1)
output	[Complex:R-MMU-158306] factor XIIa [extracellular region] [Complex:R-MMU-9857960] KLKB1:KNG1:(C1QBP, C1QBP:KRT1, PLAUR:KRT1) [plasma membrane]
precedingEvent	[Reaction:R-MMU-9855685] factor XII + prekallikrein:kininogen:cell surface receptor -> prekallikrein:kininogen:cell surface receptor:factor XII - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9857814
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) [Reaction:R-MMU-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) [Reaction:R-MMU-9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst)
(hasEvent)	[Pathway:R-MMU-9970672] FXIIa activates plasma kallikrein-kinin system
(inferredTo)	[Reaction:R-HSA-9857814] prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface)

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