Reactome | TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst)

Schema > Reaction > Entries

TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst) Show undefined attributes

catalystActivity	[CatalystActivity:10093563] serine-type endopeptidase activity of TF:FVIIa [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10093565
displayName	TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst)
eventOf	[Pathway:R-MMU-9769735] Initiation of coagulation cascade - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9931624] TFPI?:FV intermediate:PROS1 binds TF:FVIIa:FXa - Mus musculus [Reaction:R-MMU-9822556] TFPI? binds TF:FVIIa:FXa - Mus musculus [Reaction:R-MMU-9929060] TF:FVII:FXa ->TF:FVIIa:FXa (FXa catalyst) - Mus musculus [Reaction:R-MMU-9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa - Mus musculus [Reaction:R-MMU-9822522] factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst) - Mus musculus
inferredFrom	[Reaction:R-HSA-9822514] TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst) - Homo sapiens
input	[SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] [Complex:R-MMU-140739] factor X [extracellular region] [Complex:R-MMU-140734] TF:FVIIa [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst) TF:FVIIa converts FX to FXa activation of factor X by TF:FVIIa
output	[EntityWithAccessionedSequence:R-MMU-140785] F10 [extracellular region] [Complex:R-MMU-9822516] TF:FVIIa:FXa [plasma membrane]
precedingEvent	[Reaction:R-MMU-140748] tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex - Mus musculus [Reaction:R-MMU-9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa - Mus musculus
regulatedBy	[PositiveRegulation:9854651] Positive regulation by 'APLs [external side of plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9822514
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-9931624] TFPI?:FV intermediate:PROS1 binds TF:FVIIa:FXa [Reaction:R-MMU-9822556] TFPI? binds TF:FVIIa:FXa [Reaction:R-MMU-9822522] factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst) [Reaction:R-MMU-9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa [Reaction:R-MMU-9929060] TF:FVII:FXa ->TF:FVIIa:FXa (FXa catalyst)
(hasEvent)	[Pathway:R-MMU-9769735] Initiation of coagulation cascade
(inferredTo)	[Reaction:R-HSA-9822514] TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst)