Reactome | TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10093404] ubiquitin-protein transferase activity of TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[BlackBoxEvent:R-MMU-9817362] SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10093243
displayName	TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane]
hasComponent	[Complex:R-MMU-9796690] CYLD:SPATA2:LUBAC [cytosol] [Complex:R-MMU-5357756] TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-9796343] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] - Homo sapiens
maxDepth	6
name	TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD
producedByEvent	[Reaction:R-MMU-9796379] CYLD:SPATA2:LUBAC binds TNFR1 signaling complex - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-9796343
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[BlackBoxEvent:R-MMU-9817362] SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex
(physicalEntity)	[CatalystActivity:10093404] ubiquitin-protein transferase activity of TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane]
(output)	[Reaction:R-MMU-9796379] CYLD:SPATA2:LUBAC binds TNFR1 signaling complex
(inferredTo)	[Complex:R-HSA-9796343] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane]

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