Reactome | mRNA Polyadenylation

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mRNA Polyadenylation Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101905
displayName	mRNA Polyadenylation
eventOf	[Pathway:R-MMU-72187] mRNA 3'-end processing - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:9909933] co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-9770560] Formation of the CPSF complex - Mus musculus [Reaction:R-MMU-9770559] Formation of the CSTF complex - Mus musculus [Reaction:R-MMU-9968762] NUDT21 dimerizes - Mus musculus [Reaction:R-MMU-9770557] Formation of the CF I complex - Mus musculus [Reaction:R-MMU-9770564] Formation of the CF II complex - Mus musculus [Reaction:R-MMU-9770123] Formation of the core cleavage and polyadenylation complex - Mus musculus [Reaction:R-MMU-9970141] Core CPA complex binds capped pre-mRNA - Mus musculus [Reaction:R-MMU-9970179] Recruitment of other CPA components to pre-mRNA-bound CPA core - Mus musculus [Reaction:R-MMU-9970190] PP1 dephosphorylates RNA Pol II - Mus musculus [BlackBoxEvent:R-MMU-9970191] RBBP6 activates CPSF complex - Mus musculus [BlackBoxEvent:R-MMU-9970189] PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS - Mus musculus [BlackBoxEvent:R-MMU-9970318] PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS - Mus musculus [BlackBoxEvent:R-MMU-9970320] PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS - Mus musculus [BlackBoxEvent:R-MMU-9970428] CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) - Mus musculus [BlackBoxEvent:R-MMU-9970431] CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) - Mus musculus [BlackBoxEvent:R-MMU-9970429] CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) - Mus musculus
inferredFrom	[Pathway:R-HSA-9770562] mRNA Polyadenylation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	mRNA Polyadenylation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-9770562
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(inferredTo)	[Pathway:R-HSA-9770562] mRNA Polyadenylation
(hasEvent)	[Pathway:R-MMU-72187] mRNA 3'-end processing

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