Reactome | Expression of Lhx1 in intermediate mesoderm

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Expression of Lhx1 in intermediate mesoderm Show undefined attributes

authored	[InstanceEdit:9761181] May, Bruce, 2022-01-10
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9761189] May, Bruce, 2022-01-11
dbId	9761171
displayName	Expression of Lhx1 in intermediate mesoderm
edited	[InstanceEdit:9761181] May, Bruce, 2022-01-10
input	[EntityWithAccessionedSequence:R-MMU-9761201] Lhx1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9761194] Nephric lineage specification by Pax2 and Pax8 [LiteratureReference:9761190] Lim1 activity is required for intermediate mesoderm differentiation in the mouse embryo [LiteratureReference:9774508] Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms [LiteratureReference:9774484] Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development [LiteratureReference:9774485] Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development [LiteratureReference:9774609] Requirement for Lim1 in head-organizer function
maxDepth	1
modified	[InstanceEdit:9835794] Matthews, Lisa, 2023-05-17
name	Expression of Lhx1 in intermediate mesoderm
orthologousEvent	[BlackBoxEvent:R-HSA-9761166] Expression of LHX1 in intermediate mesoderm - Homo sapiens
output	[EntityWithAccessionedSequence:R-MMU-9761161] Lhx1 [nucleoplasm]
regulatedBy	[PositiveGeneExpressionRegulation:9774492] Positive gene expression regulation by 'Pax2:Lhx1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9774522] Positive gene expression regulation by 'Osr1 [nucleoplasm]' [NegativeGeneExpressionRegulation:9792540] Negative gene expression regulation by 'Foxc1 [nucleoplasm]' [NegativeGeneExpressionRegulation:9792549] Negative gene expression regulation by 'Foxc2 [nucleoplasm]'
regulationReference	[RegulationReference:9774493] Positive gene expression regulation by 'Pax2:Lhx1 gene [nucleoplasm]' A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis [RegulationReference:9774500] Positive gene expression regulation by 'Osr1 [nucleoplasm]' Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development [RegulationReference:9792548] Negative gene expression regulation by 'Foxc1 [nucleoplasm]' The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate [RegulationReference:9792552] Negative gene expression regulation by 'Foxc2 [nucleoplasm]' The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate
releaseDate	2023-06-07
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9833800] Tam, Patrick P L, 2023-05-03
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9761171
summation	[Summation:9761198] Lhx1 is expressed in developing lateral plate mesoderm and i...

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