Reactome | Ubiquitination of IKBKG by TRAF6

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Ubiquitination of IKBKG by TRAF6 Show undefined attributes

catalystActivity	[CatalystActivity:10092142] ubiquitin-protein transferase activity of K63pUb-TRAF6:TAK1 complexes [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10092146
displayName	Ubiquitination of IKBKG by TRAF6
eventOf	[Pathway:R-MMU-445989] TAK1-dependent IKK and NF-kappa-B activation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9758604] Ubiquitination of IKBKG by TRAF6 - Homo sapiens
input	[Complex:R-MMU-202513] CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] 3 × [DefinedSet:R-MMU-113595] Ub [cytosol] [Complex:R-MMU-202463] UBE2N:UBE2V1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Ubiquitination of IKBKG by TRAF6
output	[Complex:R-MMU-202562] CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] [Complex:R-MMU-202463] UBE2N:UBE2V1 [cytosol]
regulatedBy	[NegativeRegulation:10092147] Negative regulation by 'CHUK:IKBKB:IKBKG:USP18 [cytosol]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9758604
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-445989] TAK1-dependent IKK and NF-kappa-B activation
(inferredTo)	[BlackBoxEvent:R-HSA-9758604] Ubiquitination of IKBKG by TRAF6

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