Reactome | LRAT esterifies RBP2:atROL and FACYLs to atREs

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LRAT esterifies RBP2:atROL and FACYLs to atREs Show undefined attributes

catalystActivity	[CatalystActivity:10025401] phosphatidylcholine-retinol O-acyltransferase activity of LRAT [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10025403
displayName	LRAT esterifies RBP2:atROL and FACYLs to atREs
eventOf	[Pathway:R-MMU-975634] Retinoid metabolism and transport - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-2395764] atREs binds to nascent CM - Mus musculus
inferredFrom	[Reaction:R-HSA-975608] LRAT esterifies RBP2:atROL and FACYLs to atREs - Homo sapiens
input	[SimpleEntity:R-ALL-429802] PC [plasma membrane] [Complex:R-MMU-975626] RBP2:atROL [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LRAT esterifies RBP2:atROL and FACYLs to atREs all-trans-retinol--(retinol-binding protein) + a 1,2-diacyl-sn-glycero-3-phosphocholine => apo--(retinol-binding protein) + an all-trans-retinyl ester + a 2-acyl-sn-glycero-3-phosphocholine
output	[SimpleEntity:R-ALL-9982479] 2acPC [plasma membrane] [SimpleEntity:R-ALL-9982625] atRE [cytosol] [EntityWithAccessionedSequence:R-MMU-975603] RBP2 [cytosol]
precedingEvent	[Reaction:R-MMU-975633] atROL binds to RBP2 - Mus musculus [Reaction:R-MMU-975629] RDH11 reduces RBP2:atRAL to RBP2:atROL - Mus musculus [Reaction:R-MMU-2855252] AKRs reduce RBP2:atRAL to RBP2:atROL - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-975608
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-975634] Retinoid metabolism and transport
(precedingEvent)	[Reaction:R-MMU-2395764] atREs binds to nascent CM
(inferredTo)	[Reaction:R-HSA-975608] LRAT esterifies RBP2:atROL and FACYLs to atREs

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