Reactome | PNP trimer transforms RBV to T-CONH2

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PNP trimer transforms RBV to T-CONH2 Show undefined attributes

catalystActivity	[CatalystActivity:9988890] purine-nucleoside phosphorylase activity of PNP trimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10092014
displayName	PNP trimer transforms RBV to T-CONH2
eventOf	[Pathway:R-MMU-9755088] Ribavirin ADME - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9755044] PNP trimer transforms RBV to T-CONH2 - Homo sapiens
input	[SimpleEntity:R-ALL-9755011] phosphate [cytosol] [ChemicalDrug:R-ALL-9680963] RBV [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PNP trimer transforms RBV to T-CONH2 PNP breaks down ribavirin to T-CONH2
output	[SimpleEntity:R-ALL-112016] R1P [cytosol] [SimpleEntity:R-ALL-9754909] T-CONH2 [cytosol]
precedingEvent	[Reaction:R-MMU-9754934] SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol - Mus musculus [BlackBoxEvent:R-MMU-9755078] NT5C2 tetramer dephosphorylates RBV-MP - Mus musculus [Reaction:R-MMU-9755015] SLC29A1 transports RBV from extracellular region to cytosol - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9755044
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9755088] Ribavirin ADME
(inferredTo)	[Reaction:R-HSA-9755044] PNP trimer transforms RBV to T-CONH2

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