Reactome | Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation

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Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation Show undefined attributes

category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10025241
displayName	Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation
eventOf	[Pathway:R-MMU-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Mus musculus
inferredFrom	[Reaction:R-HSA-975142] Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation - Homo sapiens
input	[CandidateSet:R-MMU-450819] p-Pellino-1,2,(3) [cytosol] [Complex:R-MMU-975150] TRAF6:hp-IRAK1 [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation
output	[Complex:R-MMU-975166] p-Pellino:hp-IRAK1:TRAF6 [endosome membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-975142
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
(precedingEvent)	[Reaction:R-MMU-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
(inferredTo)	[Reaction:R-HSA-975142] Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation

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