Reactome | Expression of Mef2c in cardiogenesis

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Expression of Mef2c in cardiogenesis Show undefined attributes

authored	[InstanceEdit:9734558] May, Bruce, 2021-06-17
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9734576] May, Bruce, 2021-06-17
dbId	9734581
displayName	Expression of Mef2c in cardiogenesis
edited	[InstanceEdit:9734558] May, Bruce, 2021-06-17
input	[EntityWithAccessionedSequence:R-MMU-9022083] Mef2c gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9734592] Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development [LiteratureReference:9735213] The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors [LiteratureReference:9735166] NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes [LiteratureReference:9749082] Myocyte enhancer factor 2C and Nkx2-5 up-regulate each other's expression and initiate cardiomyogenesis in P19 cells [LiteratureReference:9735293] The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development [LiteratureReference:9749839] Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development [LiteratureReference:9763749] A threshold of GATA4 and GATA6 expression is required for cardiovascular development
maxDepth	1
modified	[InstanceEdit:9833806] Matthews, Lisa, 2023-05-03
name	Expression of Mef2c in cardiogenesis
orthologousEvent	[BlackBoxEvent:R-HSA-9734572] Expression of MEF2C in cardiogenesis - Homo sapiens
output	[EntityWithAccessionedSequence:R-MMU-1605569] Mef2c [nucleoplasm]
regulatedBy	[PositiveGeneExpressionRegulation:9734589] Positive gene expression regulation by 'Gata4:Isl1:Nkx2-5:Mef2c gene [nucleoplasm]'
regulationReference	[RegulationReference:9750531] Positive gene expression regulation by 'Gata4:Isl1:Nkx2-5:Mef2c gene [nucleoplasm]' Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development
releaseDate	2023-06-07
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9734581
summation	[Summation:9749068] The Mef2c gene is transcribed to yield mRNA and the mRNA is ...