Reactome | MLKL binds FLOT1, FLOT2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10089940
displayName	MLKL binds FLOT1, FLOT2
eventOf	[Pathway:R-MMU-5675482] Regulation of necroptotic cell death - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9688456] MLKL binds FLOT1, FLOT2 - Homo sapiens
input	[Complex:R-MMU-9688487] FLOT1:FLOT2 [plasma membrane] [Complex:R-MMU-5357794] p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MLKL binds FLOT1, FLOT2
output	[Complex:R-MMU-9688468] p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9688456
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-5675482] Regulation of necroptotic cell death
(inferredTo)	[Reaction:R-HSA-9688456] MLKL binds FLOT1, FLOT2