Reactome | Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11

Schema > BlackBoxEvent > Entries

Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11 Show undefined attributes

authored	[InstanceEdit:9674838] May, Bruce, 2020-01-27
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9674890] May, Bruce, 2020-01-29
dbId	9674973
displayName	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11
edited	[InstanceEdit:9674838] May, Bruce, 2020-01-27
input	[Complex:R-MMU-9676066] Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-2685613] Gab2 [cytosol] [EntityWithAccessionedSequence:R-MMU-443287] Grb2 [cytosol] [EntityWithAccessionedSequence:R-MMU-210002] Ptpn11 [cytosol] [EntityWithAccessionedSequence:R-MMU-1248757] Shc1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9674956] Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor [LiteratureReference:9674942] Contribution of the membrane-distal tyrosine in intracellular signaling by the granulocyte colony-stimulating factor receptor [LiteratureReference:9674958] Specific involvement of tyrosine 764 of human granulocyte colony-stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes [LiteratureReference:9674917] Proliferation signaling and activation of Shc, p21Ras, and Myc via tyrosine 764 of human granulocyte colony-stimulating factor receptor [LiteratureReference:9674923] Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route [LiteratureReference:9674936] G-CSF stimulates Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation [LiteratureReference:9674915] M-CSF elevates c-Fos and phospho-C/EBPalpha(S21) via ERK whereas G-CSF stimulates SHP2 phosphorylation in marrow progenitors to contribute to myeloid lineage specification [LiteratureReference:9639352] SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis [LiteratureReference:9690948] G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase [LiteratureReference:9690949] G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11
orthologousEvent	[BlackBoxEvent:R-HSA-9674808] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) - Homo sapiens
output	[Complex:R-MMU-9674910] Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:p-Y-Shc1:p-Y-Gab2:Grb2:p-Y546,Y584-Ptpn11 [plasma membrane]
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9674973
summation	[Summation:9674972] Grb2, Shc, and Ptpn11 bind the cytosolic domain of Csf3r (Gc...