Reactome | Outer hair cell stereocilium tip [cytosol]

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Outer hair cell stereocilium tip [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-9663248] Outer hair cell stereocilium cytoskeleton [cytosol] - Mus musculus
created	[InstanceEdit:9662417] May, Bruce, 2019-09-23
dbId	9662389
displayName	Outer hair cell stereocilium tip [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-MMU-9610535] Cask [cytosol] [EntityWithAccessionedSequence:R-MMU-9662412] Eps8 [cytosol] [EntityWithAccessionedSequence:R-MMU-9663257] Eps8l2 [cytosol] [EntityWithAccessionedSequence:R-MMU-9662402] Espn [cytosol] [EntityWithAccessionedSequence:R-MMU-9671877] Espnl [cytosol] [Polymer:R-MMU-9662413] f-Actb [cytosol] [Polymer:R-MMU-9662392] f-Actg1 [cytosol] [EntityWithAccessionedSequence:R-MMU-9662395] Gsn [cytosol] [EntityWithAccessionedSequence:R-MMU-9663224] Mpp1 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-9662399] Myo15a [cytosol] [EntityWithAccessionedSequence:R-MMU-9663309] Myo3a [cytosol] [EntityWithAccessionedSequence:R-MMU-9663311] Myo3b [cytosol] [EntityWithAccessionedSequence:R-MMU-9663282] Twf2 [cytosol] [EntityWithAccessionedSequence:R-MMU-9658871] Whrn [cytosol]
inDisease	false
includedLocation	[Compartment:876] plasma membrane
inferredTo	[Complex:R-HSA-9662408] Outer hair cell stereocilium tip [cytosol] - Homo sapiens
isChimeric	false
literatureReference	[LiteratureReference:9663226] The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells [LiteratureReference:9663027] Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8 [LiteratureReference:9662943] Distinct expression and function of whirlin isoforms in the inner ear and retina: an insight into pathogenesis of USH2D and DFNB31 [LiteratureReference:9662961] Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia [LiteratureReference:9662998] Inactivation of Cyclin-Dependent Kinase 5 in Hair Cells Causes Hearing Loss in Mice [LiteratureReference:9663262] Gelsolin plays a role in the actin polymerization complex of hair cell stereocilia [LiteratureReference:9663254] Whirlin complexes with p55 at the stereocilia tip during hair cell development [LiteratureReference:9662983] Protein 4.1 expression in the developing hair cells of the mouse inner ear [LiteratureReference:9663243] Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells [LiteratureReference:9663229] Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2 [LiteratureReference:9663310] Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth [LiteratureReference:9663296] Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like [LiteratureReference:9663302] Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions [LiteratureReference:9667734] MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear [LiteratureReference:9667699] Twinfilin 2 regulates actin filament lengths in cochlear stereocilia [LiteratureReference:9667725] Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated [LiteratureReference:9672266] Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments
maxDepth	3
modified	[InstanceEdit:9672269] May, Bruce, 2019-12-24
name	Outer hair cell stereocilium tip
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-9662389

Referrals

(hasComponent)

[Complex:R-MMU-9663248] Outer hair cell stereocilium cytoskeleton [cytosol]

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