Reactome | Raf dimer inhibitors bind RAF heterodimers

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Raf dimer inhibitors bind RAF heterodimers Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10089212
displayName	Raf dimer inhibitors bind RAF heterodimers
eventOf	[Pathway:R-MMU-5673000] RAF activation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9653108] Raf dimer inhibitors bind RAF heterodimers - Homo sapiens
input	[Complex:R-MMU-5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] [DefinedSet:R-ALL-9657579] RAF dimer inhibitors [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Raf dimer inhibitors bind RAF heterodimers
output	[Complex:R-MMU-9653109] p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane]
precedingEvent	[Reaction:R-MMU-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9653108
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5673000] RAF activation
(inferredTo)	[Reaction:R-HSA-9653108] Raf dimer inhibitors bind RAF heterodimers

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