Reactome | Intrinsic nucleotide exchange on RAS

Schema > Reaction > Entries

Intrinsic nucleotide exchange on RAS Show undefined attributes

category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10089177
displayName	Intrinsic nucleotide exchange on RAS
eventOf	[Pathway:R-MMU-5673001] RAF/MAP kinase cascade - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP - Mus musculus
inferredFrom	[Reaction:R-HSA-9649735] Intrinsic nucleotide exchange on RAS - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-MMU-109796] p21 RAS:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Intrinsic nucleotide exchange on RAS
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-MMU-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-MMU-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP - Mus musculus [Reaction:R-MMU-9649733] mature p21 RAS binds GDP - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9649735
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5673001] RAF/MAP kinase cascade
(inferredTo)	[Reaction:R-HSA-9649735] Intrinsic nucleotide exchange on RAS
(precedingEvent)	[Reaction:R-MMU-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP

Cite Us!