Reactome | LINC01139 promotes phosphorylation of HIF1A by LRRK2

Schema > Reaction > Entries

LINC01139 promotes phosphorylation of HIF1A by LRRK2 Show undefined attributes

catalystActivity	[CatalystActivity:10088527] protein serine/threonine kinase activity of HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10088529
displayName	LINC01139 promotes phosphorylation of HIF1A by LRRK2
eventOf	[Pathway:R-MMU-8857538] PTK6 promotes HIF1A stabilization - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9634702] LINC01139 promotes phosphorylation of HIF1A by LRRK2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-MMU-8857584] phospho-Hif1a [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LINC01139 promotes phosphorylation of HIF1A by LRRK2
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-MMU-9634700] phospho-Hif1a [cytosol]
precedingEvent	[Reaction:R-MMU-8857583] LINC01139 promotes phosphorylation of HIF1A by PTK6 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9634702
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8857538] PTK6 promotes HIF1A stabilization
(inferredTo)	[Reaction:R-HSA-9634702] LINC01139 promotes phosphorylation of HIF1A by LRRK2

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