Reactome | FLVCR1-1 transports heme from cytosol to extracellular region

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FLVCR1-1 transports heme from cytosol to extracellular region Show undefined attributes

catalystActivity	[CatalystActivity:10022505] heme transmembrane transporter activity of FLVCR1-1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10022507
displayName	FLVCR1-1 transports heme from cytosol to extracellular region
eventOf	[Pathway:R-MMU-917937] Iron uptake and transport - Mus musculus [Pathway:R-MMU-189451] Heme biosynthesis - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9661419] ALB binds extracellular heme - Mus musculus
inferredFrom	[Reaction:R-HSA-917892] FLVCR1-1 transports heme from cytosol to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-71185] ferroheme [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	FLVCR1-1 transports heme from cytosol to extracellular region heme b(in) = heme b(out) Export of heme to the blood by FLVCR
output	[SimpleEntity:R-ALL-917877] heme [extracellular region]
precedingEvent	[Reaction:R-MMU-9661408] FLVCR1-2 transports heme from mitochondrial matrix to cytosol - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-917892
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-189451] Heme biosynthesis [Pathway:R-MMU-917937] Iron uptake and transport
(precedingEvent)	[Reaction:R-MMU-9661419] ALB binds extracellular heme
(inferredTo)	[Reaction:R-HSA-917892] FLVCR1-1 transports heme from cytosol to extracellular region

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