Reactome | Lewis blood group biosynthesis

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Lewis blood group biosynthesis Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101759
displayName	Lewis blood group biosynthesis
eventOf	[Pathway:R-MMU-9033658] Blood group systems biosynthesis - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:25293] oligosaccharide biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-9603989] B3GALTs transfer Gal to GlcNAc-?1,3-Gal-R to form Type 1 chain - Mus musculus [Reaction:R-MMU-9603982] FUT2 transfers Fuc to LeA to form LeB - Mus musculus [Reaction:R-MMU-9603984] FUT4,5,9 transfer Fuc to Type 2 chains to form LeX - Mus musculus [Reaction:R-MMU-9603983] FUT2 transfers Fuc to LeX to form LeY - Mus musculus [Reaction:R-MMU-9603987] ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG - Mus musculus [Reaction:R-MMU-9603991] ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG - Mus musculus [Reaction:R-MMU-9605600] ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG - Mus musculus [Reaction:R-MMU-9605682] FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX - Mus musculus [Reaction:R-MMU-9605700] B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda - Mus musculus
inferredFrom	[Pathway:R-HSA-9037629] Lewis blood group biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Lewis blood group biosynthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-9037629
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9033658] Blood group systems biosynthesis
(inferredTo)	[Pathway:R-HSA-9037629] Lewis blood group biosynthesis

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