Reactome | Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Sos1 [plasma membrane]

Schema > Complex > Entries

Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Sos1 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9029081] May, Bruce, 2017-11-14
dbId	9029107
displayName	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Sos1 [plasma membrane]
hasComponent	[Complex:R-MMU-9029084] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1 [plasma membrane] [Complex:R-MMU-9029109] Grb2-1:Sos1 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
isChimeric	false
literatureReference	[LiteratureReference:9027084] Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor [LiteratureReference:9029019] Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells [LiteratureReference:9029077] Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein [LiteratureReference:9029020] The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor
maxDepth	6
memberOf	[DefinedSet:R-MMU-9029101] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 [plasma membrane] - Mus musculus
modified	[InstanceEdit:9031760] D'Eustachio, Peter, 2017-12-02
name	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Sos1
producedByEvent	[Reaction:R-MMU-9029146] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1 binds Grb2-1:Sos1 - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-9029107

Referrals

(hasMember)	[DefinedSet:R-MMU-9029101] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 [plasma membrane]
(output)	[Reaction:R-MMU-9029146] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1 binds Grb2-1:Sos1

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