Reactome | ALOX5 oxidises DHA to 7-HDHA

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10086645] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10087061
displayName	ALOX5 oxidises DHA to 7-HDHA
eventOf	[Pathway:R-MMU-9027604] Biosynthesis of electrophilic ?-3 PUFA oxo-derivatives - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9027624] ALOX5 oxidises DHA to 7-HDHA - Homo sapiens
input	[SimpleEntity:R-ALL-9024011] DHA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALOX5 oxidises DHA to 7-HDHA
output	[SimpleEntity:R-ALL-9028274] 7-HDHA [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9027624
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-9027604] Biosynthesis of electrophilic ?-3 PUFA oxo-derivatives
(inferredTo)	[Reaction:R-HSA-9027624] ALOX5 oxidises DHA to 7-HDHA

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