Reactome | Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:Shc1 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:9029165] protein tyrosine kinase activity of Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:Shc1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-MMU-9029147] Jak2 phosphorylates Shc1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef:Shc1 - Mus musculus
created	[InstanceEdit:9027241] May, Bruce, 2017-10-29
dbId	9027227
displayName	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:Shc1 [plasma membrane]
hasComponent	[Complex:R-MMU-9027244] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-1248757] Shc1 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-HSA-9027236] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:SHC1 [plasma membrane] - Homo sapiens
isChimeric	false
literatureReference	[LiteratureReference:9027195] Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells
maxDepth	5
modified	[InstanceEdit:9027444] May, Bruce, 2017-11-01
name	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:Shc1
producedByEvent	[Reaction:R-MMU-9027266] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1 binds Shc1 - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-9027227

(input)	[Reaction:R-MMU-9029147] Jak2 phosphorylates Shc1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef:Shc1
(physicalEntity)	[CatalystActivity:9029165] protein tyrosine kinase activity of Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:Shc1 [plasma membrane]
(output)	[Reaction:R-MMU-9027266] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1 binds Shc1

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