Reactome | Insulin secretory granules translocate across the cortical actin network

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Insulin secretory granules translocate across the cortical actin network Show undefined attributes

authored	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
catalystActivity	[CatalystActivity:216854] microfilament motor activity of Myo5a [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9023176] May, Bruce, 2017-09-27
dbId	9023204
deleted	[Deleted:9023241] Deletion of instance: 216855
displayName	Insulin secretory granules translocate across the cortical actin network
edited	[InstanceEdit:445324] May, B, 2009-10-29
input	[DefinedSet:R-MMU-216871] Insulin (at interior surface of cellular cortex). [secretory granule lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:445570] Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells [LiteratureReference:445561] Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic beta-cells [LiteratureReference:445572] Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation [LiteratureReference:445562] The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules [LiteratureReference:445565] MyRIP anchors protein kinase A to the exocyst complex [LiteratureReference:264260] Insulin vesicle release: walk, kiss, pause ... then run [LiteratureReference:8931605] MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Insulin secretory granules translocate across the cortical actin network
orthologousEvent	[BlackBoxEvent:R-HSA-9023171] Insulin secretory granule translocates across the cortical actin network - Homo sapiens
output	[DefinedSet:R-MMU-9023169] Insulin (post cortical actin network). [secretory granule lumen]
precedingEvent	[BlackBoxEvent:R-MMU-216852] Insulin secretory granule translocates to cell cortex - Mus musculus
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:445324] May, B, 2009-10-29
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9023204
summation	[Summation:216840] Insulin-containing secretory granules are bound to Myosin Va...
updateTrackers	[UpdateTracker:9780106] Update Tracker - [BlackBoxEvent:9023204] Insulin secretory granules translocate across the cortical actin network - v64:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9780106] Update Tracker - [BlackBoxEvent:9023204] Insulin secretory granules translocate across the cortical actin network - v64:[removeCatalystActivity]
(replacementInstances)	[Deleted:9023241] Deletion of instance: 216855

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