Reactome | WWP2 ubiquitinates NOTCH3

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WWP2 ubiquitinates NOTCH3 Show undefined attributes

catalystActivity	[CatalystActivity:10086811] ubiquitin protein ligase activity of NEXT3,NICD3:WWP2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10086813
displayName	WWP2 ubiquitinates NOTCH3
eventOf	[Pathway:R-MMU-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24614] negative regulation of Notch signaling pathway
inferredFrom	[Reaction:R-HSA-9021523] WWP2 ubiquitinates NOTCH3 - Homo sapiens
input	[Complex:R-MMU-9021521] NEXT3,NICD3:WWP2 [cytosol] [DefinedSet:R-MMU-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	WWP2 ubiquitinates NOTCH3
output	[Complex:R-MMU-9021524] Ub-NEXT3,Ub-NICD3:WWP2 [cytosol]
precedingEvent	[Reaction:R-MMU-9021520] NOTCH3 binds WWP2 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9021523
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus
(inferredTo)	[Reaction:R-HSA-9021523] WWP2 ubiquitinates NOTCH3

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