Reactome | ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE

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ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE Show undefined attributes

catalystActivity	[CatalystActivity:10086645] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10086666
displayName	ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE
eventOf	[Pathway:R-MMU-9023661] Biosynthesis of E-series 18(R)-resolvins - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9018877] LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 - Mus musculus
inferredFrom	[Reaction:R-HSA-9018894] ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE - Homo sapiens
input	[SimpleEntity:R-ALL-9023702] 5(S)-Hp-18(R)-HEPE [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE
output	[SimpleEntity:R-ALL-9023708] 5S,6S-epoxy-18(R)-HEPE [cytosol]
precedingEvent	[Reaction:R-MMU-9018863] ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9018894
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9023661] Biosynthesis of E-series 18(R)-resolvins
(precedingEvent)	[Reaction:R-MMU-9018877] LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1
(inferredTo)	[Reaction:R-HSA-9018894] ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE

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