Reactome | EGFR phosphorylates NOTCH3

Schema > Reaction > Entries

EGFR phosphorylates NOTCH3 Show undefined attributes

catalystActivity	[CatalystActivity:10086376] protein tyrosine kinase activity of EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10086378
displayName	EGFR phosphorylates NOTCH3
eventOf	[Pathway:R-MMU-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24614] negative regulation of Notch signaling pathway
inferredFrom	[Reaction:R-HSA-9018572] EGFR phosphorylates NOTCH3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-9018569] EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	EGFR phosphorylates NOTCH3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-179882] EGF:p-6Y-EGFR dimer [plasma membrane] [EntityWithAccessionedSequence:R-MMU-9018581] phospho-Notch3 [cytosol]
precedingEvent	[Reaction:R-MMU-9018573] NOTCH3 binds activated EGFR - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9018572
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus
(inferredTo)	[Reaction:R-HSA-9018572] EGFR phosphorylates NOTCH3