Reactome | CDC42 GEFs activate CDC42

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CDC42 GEFs activate CDC42 Show undefined attributes

catalystActivity	[CatalystActivity:10086094] guanyl-nucleotide exchange factor activity of CDC42 GEFs [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10086096
displayName	CDC42 GEFs activate CDC42
eventOf	[Pathway:R-MMU-9013148] CDC42 GTPase cycle - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-9692800] CDC42 translocates to the endoplasmic reticulum membrane - Mus musculus [Reaction:R-MMU-9013161] CDC42 GAPs stimulate CDC42 GTPase activity - Mus musculus
inferredFrom	[Reaction:R-HSA-9013159] CDC42 GEFs activate CDC42 - Homo sapiens
input	[Complex:R-MMU-3928558] Cdc42:GDP [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CDC42 GEFs activate CDC42
output	[Complex:R-MMU-448879] Cdc42:GTP [plasma membrane] [SimpleEntity:R-ALL-29420] GDP [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9013159
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9013148] CDC42 GTPase cycle
(precedingEvent)	[BlackBoxEvent:R-MMU-9692800] CDC42 translocates to the endoplasmic reticulum membrane [Reaction:R-MMU-9013161] CDC42 GAPs stimulate CDC42 GTPase activity
(inferredTo)	[Reaction:R-HSA-9013159] CDC42 GEFs activate CDC42