Reactome | IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3

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IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 Show undefined attributes

catalystActivity	[CatalystActivity:10084724] transmembrane receptor protein tyrosine kinase activity of IL19:IL20RA:p-JAK1:IL20RB:STAT3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10084726
displayName	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
eventOf	[Pathway:R-MMU-8854691] Interleukin-20 family signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-8982162] p?Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB - Mus musculus
inferredFrom	[Reaction:R-HSA-8982163] IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-8982170] IL19:IL20RA:p-JAK1:IL20RB:STAT3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 STAT3 is phosphorylated by IL19:IL20RA:p-JAK1:IL20RB:STAT3 activated receptor complex STAT3 is phosphorylated by IL19/IL19 receptor activated complex
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-8982168] IL19:IL20RA:p-JAK1:IL20RB:p-Y705-STAT3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-MMU-8982165] IL19:IL20RA:p?JAK1:IL20RB binds STAT3 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8982163
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8854691] Interleukin-20 family signaling
(precedingEvent)	[BlackBoxEvent:R-MMU-8982162] p?Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB
(inferredTo)	[Reaction:R-HSA-8982163] IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3

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