Reactome | RASA1 stimulates RAS GTPase activity

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RASA1 stimulates RAS GTPase activity Show undefined attributes

catalystActivity	[CatalystActivity:10084417] GTPase activity of p21 RAS:GTP:RASA1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10084419
displayName	RASA1 stimulates RAS GTPase activity
eventOf	[Pathway:R-MMU-8849471] PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8981353] RASA1 stimulates RAS GTPase activity - Homo sapiens
input	[Complex:R-MMU-8981350] p21 RAS:GTP:RASA1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RASA1 stimulates RAS GTPase activity
output	[Complex:R-MMU-109796] p21 RAS:GDP [plasma membrane] [EntityWithAccessionedSequence:R-MMU-186833] Rasa1 [cytosol]
precedingEvent	[Reaction:R-MMU-8981355] RASA1 binds RAS:GTP - Mus musculus
regulatedBy	[NegativeRegulation:10084420] Negative regulation by 'p-Y1105-ARHGAP35:RASA1 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8981353
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8849471] PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
(inferredTo)	[Reaction:R-HSA-8981353] RASA1 stimulates RAS GTPase activity

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