Reactome | PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3

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PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 Show undefined attributes

category	binding
compartment	[Compartment:17947] peroxisomal membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10083923
displayName	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3
eventOf	[Pathway:R-MMU-9033241] Peroxisomal protein import - Mus musculus [Pathway:R-MMU-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8953946] PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 - Mus musculus
inferredFrom	[Reaction:R-HSA-8953917] PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 - Homo sapiens
input	[Complex:R-MMU-9033091] PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] [Complex:R-MMU-8953915] Ub:UBE2D1,2,3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3
output	[Complex:R-MMU-8953942] PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane]
precedingEvent	[BlackBoxEvent:R-MMU-9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8953917
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9033241] Peroxisomal protein import [Pathway:R-MMU-8866654] E3 ubiquitin ligases ubiquitinate target proteins
(precedingEvent)	[Reaction:R-MMU-8953946] PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11
(inferredTo)	[Reaction:R-HSA-8953917] PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3

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