Reactome | AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex

Schema > Reaction > Entries

AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex Show undefined attributes

catalystActivity	[CatalystActivity:10083679] NEDD8 transferase activity of NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10083681
displayName	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex
eventOf	[Pathway:R-MMU-8951664] Neddylation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Mus musculus
inferredFrom	[Reaction:R-HSA-8952631] AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex - Homo sapiens
input	[Complex:R-MMU-8952578] NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex
output	[Complex:R-MMU-8952606] NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] [EntityWithAccessionedSequence:R-MMU-8951627] Ube2m [cytosol]
precedingEvent	[Reaction:R-MMU-8952630] NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8952631
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8951664] Neddylation
(precedingEvent)	[Reaction:R-MMU-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
(inferredTo)	[Reaction:R-HSA-8952631] AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex

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