Reactome | Loading of antigenic peptides on to class I MHC

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Loading of antigenic peptides on to class I MHC Show undefined attributes

category	binding
compartment	[Compartment:5263265] lumenal side of endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10082691
displayName	Loading of antigenic peptides on to class I MHC
eventOf	[Pathway:R-MMU-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-983161] Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex - Mus musculus
inferredFrom	[Reaction:R-HSA-8951499] Loading of antigenic peptides on to class I MHC - Homo sapiens
input	[SimpleEntity:R-ALL-983033] Antigen peptide [endoplasmic reticulum lumen] [Complex:R-MMU-983121] MHC:B2M peptide loading complex [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Loading of antigenic peptides on to class I MHC
output	[Complex:R-MMU-8951496] Antigenic peptide:MHC:B2M peptide loading complex [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-MMU-983158] Trimming of peptides in ER - Mus musculus [Reaction:R-MMU-983142] Formation of peptide loading complex (PLC) - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8951499
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC
(precedingEvent)	[Reaction:R-MMU-983161] Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex
(inferredTo)	[Reaction:R-HSA-8951499] Loading of antigenic peptides on to class I MHC