Reactome | IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10082663] transmembrane receptor protein tyrosine kinase activity of IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[BlackBoxEvent:R-MMU-8950757] IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10082584
displayName	IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane]
hasComponent	[Complex:R-MMU-447102] IL12A:IL12B [extracellular region] [Complex:R-MMU-8950587] IL12RB1:p-Y-TYK2 [plasma membrane] [Complex:R-MMU-8950302] IL12RB2:p-JAK2 [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-8950227] IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] - Homo sapiens
maxDepth	3
name	IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2
producedByEvent	[Reaction:R-MMU-8950423] JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-8950227
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-MMU-8950423] JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
(input)	[BlackBoxEvent:R-MMU-8950757] IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
(physicalEntity)	[CatalystActivity:10082663] transmembrane receptor protein tyrosine kinase activity of IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane]
(inferredTo)	[Complex:R-HSA-8950227] IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane]

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