Reactome | DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3

Schema > Reaction > Entries

DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 Show undefined attributes

catalystActivity	[CatalystActivity:10082336] ubiquitin-protein transferase activity of NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10082338
displayName	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3
eventOf	[Pathway:R-MMU-3134975] Regulation of innate immune responses to cytosolic DNA - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 - Homo sapiens
input	[Complex:R-MMU-8948707] NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] 3 × [DefinedSet:R-MMU-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3
output	[EntityWithAccessionedSequence:R-MMU-1604439] Dtx4 [cytosol] [EntityWithAccessionedSequence:R-MMU-3249366] NLRP4 [cytosol] [Complex:R-MMU-3465596] STING:p-S172,K48polyUb-TBK1:IRF3 [cytoplasmic vesicle membrane]
precedingEvent	[Reaction:R-MMU-3249392] NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8948709
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-3134975] Regulation of innate immune responses to cytosolic DNA
(inferredTo)	[Reaction:R-HSA-8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3

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