Reactome | FUNDC1 is phosphorylated by ULK1 at Ser17

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FUNDC1 is phosphorylated by ULK1 at Ser17 Show undefined attributes

catalystActivity	[CatalystActivity:10082304] protein serine/threonine kinase activity of ULK1 [mitochondrial outer membrane]
category	transition
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10082306
displayName	FUNDC1 is phosphorylated by ULK1 at Ser17
eventOf	[Pathway:R-MMU-8934903] Receptor Mediated Mitophagy - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8959573] Phosphorylated FUNDC1 links damaged mitochondria to LC3 - Mus musculus
inferredFrom	[Reaction:R-HSA-8948146] FUNDC1 is phosphorylated by ULK1 at Ser17 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-MMU-8934922] Fundc1 [mitochondrial outer membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	FUNDC1 is phosphorylated by ULK1 at Ser17
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-MMU-8948140] phospho-Fundc1 [mitochondrial outer membrane]
precedingEvent	[Reaction:R-MMU-8948136] ULK1 Translocates to the mitochondria - Mus musculus [Reaction:R-MMU-8948139] p-S13-FUNDC1 is dephosphorylated by PGAM5 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8948146
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8934903] Receptor Mediated Mitophagy
(precedingEvent)	[Reaction:R-MMU-8959573] Phosphorylated FUNDC1 links damaged mitochondria to LC3
(inferredTo)	[Reaction:R-HSA-8948146] FUNDC1 is phosphorylated by ULK1 at Ser17

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