Reactome | RET binds GFRA1,GFRA2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10079233
displayName	RET binds GFRA1,GFRA2
eventOf	[Pathway:R-MMU-8853659] RET signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8853789] GDNF,NRTN bind RET:GFRA1,GFRA2 - Mus musculus
inferredFrom	[Reaction:R-HSA-8871226] RET binds GFRA1,GFRA2 - Homo sapiens
input	[DefinedSet:R-MMU-8853803] GFRA1, GFRA2 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-8853797] RET [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RET binds GFRA1,GFRA2
output	[Complex:R-MMU-8855759] RET:GFRA1,GFRA2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8871226
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-8853659] RET signaling
(precedingEvent)	[Reaction:R-MMU-8853789] GDNF,NRTN bind RET:GFRA1,GFRA2
(inferredTo)	[Reaction:R-HSA-8871226] RET binds GFRA1,GFRA2

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