Reactome | PTPN12 dephosphorylates ERBB2 on tyrosine Y1248

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PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 Show undefined attributes

catalystActivity	[CatalystActivity:10077466] protein tyrosine phosphatase activity of PTPN12 [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10077468
displayName	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
eventOf	[Pathway:R-MMU-8863795] Downregulation of ERBB2 signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2455327] negative regulation of ERBB signaling pathway
inferredFrom	[Reaction:R-HSA-8863804] PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [CandidateSet:R-MMU-1963588] p-ERBB2 heterodimers [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
output	[CandidateSet:R-MMU-8863989] Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-MMU-1963582] Trans-autophosphorylation of ERBB2 heterodimers - Mus musculus [Reaction:R-MMU-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8863804
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8863795] Downregulation of ERBB2 signaling
(inferredTo)	[Reaction:R-HSA-8863804] PTPN12 dephosphorylates ERBB2 on tyrosine Y1248

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