Reactome | NTPDase5 hydrolyzes nucleoside diphosphates

Schema > Reaction > Entries

NTPDase5 hydrolyzes nucleoside diphosphates Show undefined attributes

catalystActivity	[CatalystActivity:10075733] nucleoside diphosphate phosphatase activity of NPTDase5:Ca2+,Mg2+ [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10075735
displayName	NTPDase5 hydrolyzes nucleoside diphosphates
eventOf	[Pathway:R-MMU-8850843] Phosphate bond hydrolysis by NTPDase proteins - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8940074] NT5E:Zn2+ hydrolyses NMN - Mus musculus
inferredFrom	[Reaction:R-HSA-8851356] NTPDase5 hydrolyzes nucleoside diphosphates - Homo sapiens
input	[DefinedSet:R-ALL-8936165] ADP,GDP,CDP,UDP [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	NTPDase5 hydrolyzes nucleoside diphosphates UDP + H2O => UMP + phosphate + H(+) GDP + H2O => GMP + phosphate + H(+) CDP + H2O => CMP + phosphate + H(+) ADP + H2O => AMP + phosphate + H(+)
output	[DefinedSet:R-ALL-8851369] AMP,GMP,CMP,UMP [extracellular region] [SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-109277] Pi [extracellular region]
precedingEvent	[Reaction:R-MMU-8850846] NTPDase1 hydrolyzes nucleoside triphosphates - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8851356
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-8940074] NT5E:Zn2+ hydrolyses NMN
(hasEvent)	[Pathway:R-MMU-8850843] Phosphate bond hydrolysis by NTPDase proteins
(inferredTo)	[Reaction:R-HSA-8851356] NTPDase5 hydrolyzes nucleoside diphosphates

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