Reactome | SPINK5(490-624) binds KLK5

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SPINK5(490-624) binds KLK5 Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10075376
displayName	SPINK5(490-624) binds KLK5
eventOf	[Pathway:R-MMU-6809371] Formation of the cornified envelope - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8849638] Dissociation of the SPINK5:KLK5 complex at low pH - Mus musculus
inferredFrom	[Reaction:R-HSA-8849646] SPINK5(490-624) binds KLK5 - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-8849852] Klk5 [extracellular region] [EntityWithAccessionedSequence:R-MMU-8849665] Spink5 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SPINK5(490-624) binds KLK5
output	[Complex:R-MMU-8849656] KLK5:SPINK5 [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8849646
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6809371] Formation of the cornified envelope
(precedingEvent)	[Reaction:R-MMU-8849638] Dissociation of the SPINK5:KLK5 complex at low pH
(inferredTo)	[Reaction:R-HSA-8849646] SPINK5(490-624) binds KLK5

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