Reactome | GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O

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GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O Show undefined attributes

catalystActivity	[CatalystActivity:9987306] glutathione peroxidase activity of GPX1 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9987308
displayName	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O
eventOf	[Pathway:R-MMU-3299685] Detoxification of Reactive Oxygen Species - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29450] GSH [cytosol] [SimpleEntity:R-ALL-29408] H2O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
output	[SimpleEntity:R-ALL-111745] GSSG [cytosol] 2 × [SimpleEntity:R-ALL-29356] H2O [cytosol]
precedingEvent	[Reaction:R-MMU-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Mus musculus [Reaction:R-MMU-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Mus musculus [Reaction:R-MMU-74247] XDH oxidizes hypoxanthine to form xanthine - Mus musculus [Reaction:R-MMU-74258] XDH oxidizes xanthine to form urate - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-71676
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-3299685] Detoxification of Reactive Oxygen Species
(inferredTo)	[Reaction:R-HSA-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O

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